Brain scan study to detect hidden inflammation in silent artery disease
NCT ID NCT05238961
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study was designed to use a special PET scan to measure brain inflammation in people with asymptomatic carotid artery disease (narrowing of neck arteries without symptoms). It aimed to compare inflammation levels between those with high-grade and low-grade narrowing. However, the study was withdrawn before enrolling any participants, so no results were obtained.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Expected to start
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Apr 2028
An estimate. Start dates often move.
- Expected to finish
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Apr 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Cohort 1 - Critical Asymptomatic Carotid Stenosis Group Inclusion Criteria: 1. Critical Stenosis Group: Diagnosis of Asymptomatic Carotid Artery Disease (aCAD) with \>70% stenosis or peak systolic velocity on DUS ≥ 230 cm/s plus CTA or MRA confirmation. 2. Participation in University of Alabama at Birmingham (UAB) IRB protocol "Neuroinflammation in Asymptomatic Carotid Artery Disease" (IRB-300007806, PI Lazar). 3. Male or female age \>18 years 4. English speaking with at least 8th grade education 5. High affinity binder for TSPO ligands based on genotyping for single nucleotide polymorphism (SNP) rs6971 6. Planned revascularization for aCAD in \>14 days from time of consent Cohort 2 - Non-Critical Asymptomatic Carotid Stenosis Group Inclusion Criteria: 1. Participation in UAB IRB protocol "Neuroinflammation in Asymptomatic Carotid Artery Disease" (IRB-300007806, PI Lazar). 2. \<40% carotid stenosis 3. No planned revascularization 4. Male or female age 18 or older 5. English speaking with at least 8th grade education 6. High affinity binder for TSPO ligands based on genotyping SNP rs6971 Exclusion Criteria: 1. Contraindication to MRI 2. Pregnancy or lactation 3. Previous revascularization for treatment of aCAD 4. Prior stroke 5. Severe anemia (blood hemoglobin ≤ 8 mg/dL) 6. Previously obtained MRI scan with evidence of clinically significant abnormality 7. History of traumatic head injury defined by loss of consciousness \>30 minutes or seizure at the time of the injury 8. Major depression 9. Known history of dementia 10. Serious medical comorbidity that, based on the judgement of the principal investigator, may interfere with study participation 11. Low or mixed-affinity binding for TSPO ligands based on genotyping for SNP rs6971.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.