Can a neck injection quiet the Brain's fear response in PTSD?
NCT ID NCT05391971
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting an anesthetic near certain neck nerves (stellate ganglion block) can reduce PTSD symptoms by calming overactive stress responses. About 79 adults with chronic PTSD will receive either the anesthetic or a placebo (saline) injection. Researchers will measure changes in brain activity and skin sweat responses before and after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- bupivacaine (anesthetic)
- What this could lead to
- If it works, this could offer a new, non-drug option to ease PTSD symptoms by temporarily calming the body's stress alarm system.
- What could go wrong
- This is a small, early-stage trial with only 79 participants, so results may not apply to everyone. The effect may be short-lived or no better than a placebo injection.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 4
Runs after approval, following long-term safety and how well the treatment works in everyday use.
- Participants
-
79 people
The number who actually took part.
- Started
-
Aug 2022
- Expected to finish
-
Jun 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. 18-65 years of age 2. Chronic (at least one month post-trauma) DSM-5 PTSD symptoms 3. CAPS-5 Past Month score ≥ 26 4. Meets current DSM-5 PTSD diagnosis 5. Stable medications for 3 or more months by the time of study entrance (with the exception of benzodiazepines) 6. Willing and able to provide informed consent Exclusion Criteria: 1. History of stellate ganglion block treatment 2. Allergy to local anesthetics (e.g. ropivacaine, bupivacaine) 3. Allergy to iodinated contrast agents 4. Diagnosis of bipolar I disorder with a past year manic episode 5. Diagnosis of a psychotic disorder or psychotic symptoms 6. Diagnosis of current moderate or severe substance use disorder 7. History of neurological disease (that involves the brain), seizure, or significant head trauma (i.e., extended loss of consciousness, neurological sequelae, or known structural brain lesion) 8. Significant recent suicidal ideation or significant suicidal behavior in the past 12 months or suicidal ideation with imminent risk that warrants a higher level of care 9. Concurrent trauma focused psychotherapy 10. Pregnancy (to be ruled out by urine ß-HCG) 11. Metallic implants or devices contraindicating magnetic resonance imaging by interfering with patient safety or fMRI data collection; cases will be cleared by the Principal Investigator and Center for Brain Imaging 12. Morbid obesity (BMI \>4 kg/m2) 13. Current use of opioids, cocaine, or benzodiazepines (as assessed by urine toxicology) 14. Self-injurious behavior that involves suicidal intent, requires medical attention, or occurs daily. 15. Cardiac conditions or any prior heart surgeries 16. Respiratory conditions such as COPD or untreated asthma 17. History of heavy metal poisoning 18. History of neck or throat surgeries 19. Vocal cord problems or paralysis 20. Untreated high blood pressure 21. Current cancer diagnosis 22. Diagnosis of Guillain-Barré syndrome 23. Diagnosis of Parkinson's Disease 24. Unable to take 7 days off of blood thinners
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Post traumatic stress disorder are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
NYU Langone Health
New York, New York, 10016, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Five sessions to quiet trauma nightmares in bipolar disorder
- Can training hospital staff in Trauma-Informed care make childbirth safer?
- Scientists probe brain's reward system in mental illness
- Can a mindfulness class help veterans with concussion and PTSD?
- Can MDMA plus therapy help veterans fight both PTSD and alcohol addiction?
- Can talk therapies quiet the trauma of violence?