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Eye pain mystery: scientists probe nerve link in dry eye sufferers

NCT ID NCT04838223

Knowledge-focused Sponsor: Tufts Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how common nerve problems are in people who feel eye discomfort. Researchers will test 1,000 participants to see if their pain is linked to nerve damage rather than just dry eye. The goal is to better understand these conditions and improve diagnosis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

1,000 subjects will be enrolled for this study based on the above criteria:

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Presents with ocular surface discomfort or for dry eye care * Best corrected visual acuity of 20/40 or better in each eye * Subject reported duration of symptoms of at least 3 months * 100 subjects will be required to be habitual contact lens wearers as defined by use of contact lenses at least 5 hours per day at least 5 days per week for the last year. Exclusion Criteria: * Use of contact lenses on the day of the visit * Pregnant or nursing * Irregular corneas (e.g., ectatic disease, transplantation, or corneal dystrophies) * Ocular surgery in the past 3 months * Ocular infection in the past 3 months * Active ocular allergies

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Conditions

The condition(s) this trial relates to.

dry eye syndrome neuralgia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dry eye Neuropathic pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    16 sites. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Baylor College of Medicine

    Houston, Texas, 77030, United States

  • Bruce W. Carter VA Medical Center

    Miami, Florida, 33125, United States

  • Canyon City Eye Care

    Azusa, California, 91702, United States

  • Hospital of the University of Pennsylvania (Scheie Eye Institute Perelman)

    Philadelphia, Pennsylvania, 19104, United States

  • Illinois College of Optometry

    Chicago, Illinois, 60616, United States

  • Kannarr Eye Care

    Pittsburg, Kansas, 66762, United States

  • Korb & Associates

    Boston, Massachusetts, 02215, United States

  • Midwest Vision Research Foundation at Prepose Vision Institute

    St Louis, Missouri, 63128, United States

  • Ophthalmology Associates

    St Louis, Missouri, 63131, United States

  • SkyVision Centers

    Westlake, Ohio, 44145, United States

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • University of California at San Francisco - Francis I Proctor Foundation

    San Francisco, California, 94143, United States

  • University of Illinois at Chicago

    Chicago, Illinois, 60612, United States

  • University of Maryland

    Baltimore, Maryland, 21201, United States

  • Vita Eye Clinic

    Shelby, North Carolina, 28150, United States

  • Western University of Health Sciences

    Pomona, California, 91766, United States

More trials for these conditions

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