Cannabis-Like Drug's brain impact revealed in healthy volunteers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 19-65 years old. For safety reasons, we will ask participants to provide photo ID showing birthdate, in order to verify age. * The ability to tolerate complete dosing regimen of nabilone (2mg titrated, 1 week course) * Able to sign and date informed consent form. * Willing and able to complete study as described in protocol Exclusion Criteria: * Serious, unstable medical condition including but not limited to cerebrovascular, renal, hepatic and coronary heart disease; * Coagulation/Blood Disorders or use of anticoagulant medication * Past or current neurological illness or head trauma; * Lifetime diagnosis of DSM-5 Axis I psychiatric conditions including mood, anxiety, eating, somatoform and/or psychotic disorders and substance abuse and/or dependence; * Suicidality or history of suicide attempts; * Family history of psychotic disorders (first degree relative with a psychotic disorder); * Current use (\~30 days) of drugs of abuse that may affect the CNS, including cannabis; * Tobacco dependence (Fagerstrom Test for Nicotine Dependence \>4); * Pregnancy or breastfeeding; * Presence of metal objects in the body or implanted electronic devices, that preclude safe MR scanning; * Claustrophobia; * Known sensitivity to marijuana or other cannabinoid agents; * Are on medications known to interact with nabilone such as: diazepam, sodium secobarbital, alcohol, codeine, any medications that affect mental and/or psychomotor function; * Positive during drug screening for drugs of abuse; * Exposure to radiation \<20 mSv in the last 12 months and a number of PET scans that, including the number of PET scans under this protocol, will bring the total to more than 8 PET scans/lifetime, exceeding permissible limit for subjects participating in research set by Brain Health Imaging Centre Guideline; * Participant has any other problem that, in the investigators opinion, would preclude participation in the trial;