Common supplement may cut opioid need after hysterectomy
NCT ID NCT06039566
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether giving n-acetylcysteine (NAC) during hysterectomy surgery can lower the amount of opioids needed for pain afterward. About 240 women having laparoscopic or robotic hysterectomy will receive either NAC or a placebo. Researchers will track pain scores and opioid use for 72 hours after surgery to see if NAC helps ease pain with fewer opioids.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 240 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Nov 2023
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion * Undergoing elective laparoscopic or robotic, full, or partial hysterectomy procedure * 18 years of age and older Exclusion * Less than 40kg in weight * Unable to provide written, informed consent * History of an adverse or anaphylactoid reaction to acetylcysteine * Active asthma, wheezing, or using inhaled bronchodilators * Non-English speaking * Insulin dependent diabetes if D5W is required * Blood clotting disorders
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Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Medical University of South Carolina
RECRUITINGCharleston, South Carolina, 29425, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a smart sensor rebuild pelvic health after hysterectomy?
- Can a routine surgical step prevent ureter injuries in hysterectomy?
- A simple pressure test before surgery might reveal your risk of chronic pain
- Can a ketamine boost during surgery slash opioid needs?
- Can watching videos before surgery calm nerves?
- Can a targeted nerve block cut opioid use after hysterectomy?