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Can a ketamine boost during surgery slash opioid needs?

NCT ID NCT03231683

Symptom relief Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 14, 2026 · Last updated Aug 14, 2026

Summary

This trial tests whether giving a low dose of ketamine during anesthesia can reduce the amount of morphine needed for pain relief in the first 24 hours after an abdominal hysterectomy. It also looks at whether this approach lowers common opioid side effects like nausea, vomiting, and itching. The study involves 90 women undergoing open hysterectomy for benign conditions, with half receiving ketamine and half receiving a placebo, in a double-blinded setup.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Low-dose esketamine (S+ ketamine) given intravenously during anesthesia
What this could lead to
If effective, this could offer a way to reduce opioid use and related side effects after hysterectomy, improving recovery.
What could go wrong
This is a small, early-phase trial, so results may not be conclusive. Ketamine can cause side effects like nausea or psychotomimetic effects, and the benefit over placebo is uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

90 people

The number who actually took part.

Start date

Mar 2014

Finished

May 2016

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female ASA I/II patients above age of 21 years old scheduled gynecological open surgery for benign condition (fibroids, adenomyosis), who are willing and able to give written informed consent for participation in this study. Exclusion Criteria: * Contraindications to the use of S+ ketamine, as listed in the product label e.g. untreated or insufficiently treated thyroid hyperfunction, unstable angina pectoris or myocardial infarction within the last 6 months, diseases of the central nervous system, increased intraocular pressure and perforating ocular injuries, surgical procedures in the upper respiratory tract; * History of drug or alcohol abuse; * Regular use of analgesics, or use of opioids within 12 hours of surgery; * Chronic use of benzodiazepine or neuroleptics; * Thyroid replacement hormone; * History of ischaemic heart disease, hypertension, psychiatric disorder; * BMI\> 30kg/m2; * Laparoscopic surgery converted to open surgery; * Pregnant or breast feeding females.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia Hysterectomy Ketamine Morphine

Contacts and locations

Locations

  • Kk Women'S and Children'S Hospital

    Singapore, 229899, Singapore

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