Can a common supplement help tame alcohol cravings and PTSD symptoms?
NCT ID NCT02966873
First seen Apr 13, 2026 · Last updated Jun 22, 2026 · Updated 11 times
Summary
This study tested whether N-acetylcysteine (NAC), a widely available supplement, could help people with both alcohol use disorder and PTSD. 182 adults took either NAC or a placebo daily for 12 weeks, along with weekly therapy. Researchers measured changes in drinking habits, cravings, and PTSD symptoms to see if NAC offered any extra benefit.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Medical University of South Carolina
Charleston, South Carolina, 29401, United States
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The Charleston Center
Charleston, South Carolina, 29425, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
N-acetylcysteine (NAC)
What this could lead to
If it works, this could point toward a new treatment option for people struggling with both alcohol use disorder and PTSD.
What could go wrong
This is a Phase 2 trial with 182 participants, so results are preliminary. The supplement NAC may not prove effective, and individual responses can vary.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.