Botulinum toxin injection studied for stiff legs after stroke or injury
NCT ID NCT04099667
First seen May 26, 2026 · Last updated Jun 23, 2026 · Updated 7 times
Summary
This study tested whether MYOBLOC, a botulinum toxin type B injection, can safely reduce muscle stiffness in the lower legs of adults who developed spasticity after a stroke, brain injury, or spinal cord injury. The trial planned to enroll about 40 participants but was terminated early. Researchers measured changes in muscle tone and overall function four weeks after a single injection.
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Centrum Medyczne Linden
Krakow, 31-721, Poland
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Coastal Neurology
Port Royal, South Carolina, 29935, United States
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Idaho Physical Medicine and Rehabilitation
Boise, Idaho, 83706, United States
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National Institute of Medical Rehabilitation
Budapest, H-1121, Hungary
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Niepubliczny Zaklad Opieki Zdrowotnej (NZOZ) Neuromed
Lubin, 20-604, Poland
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Rancho Research Institute
Downey, California, 90242, United States
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Specjalistyczna Praktyka Lekarska
Katowice, 40-097, Poland
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Specjalistyczne Gabinety
Krakow, 30-539, Poland
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University of Texas Southwestern Medical Center
Dallas, Texas, 75390, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MYOBLOC (rimabotulinumtoxinB, a botulinum toxin type B injection)
What this could lead to
If it works, this could provide a treatment option to reduce leg muscle stiffness and improve movement in adults with spasticity.
What could go wrong
The trial was terminated early with only 40 participants, so results are limited. Botulinum toxin injections carry risks like muscle weakness or allergic reactions.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.