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Scientists uncover how muscles grow and shrink at the protein level

NCT ID NCT06350591

Knowledge-focused Sponsor: Queen's University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at how resistance exercise and leg immobilization affect muscle protein production in 15 healthy women aged 18-30. Participants did leg exercises with one leg while the other leg was immobilized. Researchers measured changes in muscle protein synthesis and breakdown to better understand muscle growth and loss. The goal is to inform future treatments for muscle wasting due to aging, disease, or inactivity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help develop better therapies to prevent muscle loss from aging, disease, or disuse.
What could go wrong
This is a small, early-stage study in healthy young women only, so findings may not apply to older adults or people with medical conditions. It is observational and not testing a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15 people

The number who actually took part.

Started

Apr 2024

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Females 18-30 years * BMI between 18-28 kg/m2 * ≥2 days per week of structured exercise * Generally healthy as assessed by medical and physical activity questionnaires * Participants not currently pregnant Exclusion Criteria: * Any muscular, neurological, respiratory, or metabolic disease including diabetes * Any form of cancer currently or in the last 5 years * Bleeding disorders or antiplatelet / anticoagulation therapy * Currently taking fish oils or within the last 6 months * Currently taking any form of steroid or within the last 3 months * Inability to attain magnetic resonance imaging scans * Known irregular responses to physical activity (e.g., shortness of breath, chest pain, dizziness, etc.) * Any current illness * Currently smoking or smoking within the last 6 months * Currently pregnant * Any concurrent medical, psychiatric, or orthopedic condition that, subject to investigators' discernment, would negatively affect the subject's ability to comply with the study requirements

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Conditions

The condition(s) this trial relates to.

muscular atrophy myostatin-related muscle hypertrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Healthy Skeletal muscle atrophy Skeletal muscle hypertrophy

Contacts and locations

Locations

  • School of Kinesiology and Health Studies

    Kingston, Ontario, K7L 3N6, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.