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Exercise's secret messages: Muscle-to-Fat cell talk revealed

NCT ID NCT04500769

Knowledge-focused Sponsor: Yuan Wen Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at tiny particles called extracellular vesicles that muscles release after a single session of strength training. Researchers want to see if these particles carry signals to fat cells, and whether this process differs between healthy-weight and obese young adults. The goal is to better understand how exercise influences metabolism at a molecular level.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Acute Resistance Exercise (Strength Training)
What this could lead to
If successful, this could reveal how exercise benefits metabolism at a cellular level, potentially guiding future treatments for obesity or diabetes.
What could go wrong
This is a small, early-stage observational study with only 38 participants. Results may not apply to everyone, and it does not test a direct treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

38 people

The number who actually took part.

Started

Mar 2019

Finished

Nov 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 30 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-30 years of age. * Either BMI \<25 or \>30. * Relatively sedentary, reporting no participation in regular (\>1 day per week) exercise for at least the past 3 months. * Non-smoker. Exclusion Criteria: * BMI between 25 and 30. * Evidence or signs and symptoms for cardiovascular disease (previous heart attack, arrhythmias, angina, shortness of breath, extreme fatigue, unusual pain in neck, jaw, throat, upper abdomen, or back, swelling in feet, legs, or ankles). * Evidence or signs and symptoms of metabolic syndrome or disorder (diagnosis of diabetes or insulin resistance, elevated BP, high fasting blood sugar, abnormal cholesterol or triglyceride levels). * Chronic aspirin or NSAID use (unless it can be safely stopped prior to the biopsies), and any other use of an anticoagulant (e.g., Coumadin) or history of bleeding including history of hypo- or hyper-coagulation disorders. * Neurological, musculoskeletal, or other disorder that would preclude safe participation in the weight lifting tasks and all performance tests. * Any other medical condition that would interfere with testing or increase one's risk of complications during exercise, as judged by the study physician. * Any other condition or events considered exclusionary by the PI and/or physician, such as non-compliance. * Lidocaine allergy (1% lidocaine is the local anesthetic used during the muscle biopsy procedure). * Pregnancy.

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Conditions

The condition(s) this trial relates to.

metabolic disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Metabolism

Contacts and locations

Locations

  • University of Kentucky

    Lexington, Kentucky, 40536, United States

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Other studies related to the condition(s) this trial covers.