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Brain training and exercise combo shows promise for mild memory loss

NCT ID NCT05483790

Symptom relief Sponsor: Huashan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study tested a multimodal program combining cognitive training, physical exercise, and healthy lifestyle education in 120 older adults (ages 50-75) with mild cognitive impairment or normal cognition. Participants were randomly assigned to the program or health education alone. The goal was to see if the program could improve memory and thinking, measured by tests and brain scans over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
multimodal behavioral intervention (cognitive training, physical exercise, healthy lifestyle education, and computerized interaction training)
What this could lead to
If it works, this could point toward a simple, non-drug program to help older adults maintain or improve memory and thinking skills.
What could go wrong
This is a small, completed study with 120 participants, so results may not apply to everyone. The intervention is complex and may be hard to replicate widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

120 people

The number who actually took part.

Started

Jun 2020

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Aged ≥50 and ≤75 years, Male or Female 2. The resident elderly or those who have lived in the sampled community for more than 6 months 3. Be able to communicate with investigators and understand the questionnaire questions 4. More than 6 years of education 5. Mild cognitive impairment according to the Peterson criteria 6. Volunteer to participate in the study Exclusion Criteria: 1. Individuals with neurological diseases 2. Cognitive decline due to other disorders (cerebrovascular disease, central nervous system infections, etc.) 3. Mental Disorders included in The Diagnostic and Statistical Manual of Mental Disorders of The American Psychiatric Association 4. Blindness, aphasia, or severe hearing impairment 5. History of myocardial infarction within the previous year, Unstable cardiac, renal, lung, liver or other severe chronic diseases 6. Coincident participation in another intervention trial 7. Using pharmacologic therapeutics for cognitive impairment.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild cognitive impairment The cognitive normal elderly

Contacts and locations

Locations

  • Huashan Hospital, Fudan University

    Shanghai, Shanghai Municipality, 200030, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.