New hope for scleroderma patients as experimental drug enters mid-stage trial
NCT ID NCT07287670
First seen Jan 05, 2026 · Last updated May 23, 2026 · Updated 24 times
Summary
This study tests whether the experimental drug MTX-474 can safely reduce skin thickening in people with diffuse cutaneous systemic sclerosis, a rare autoimmune disease that causes hard, tight skin and can damage internal organs. About 85 adults with early-stage disease will receive either MTX-474 or a placebo for 24 weeks. The main goal is to measure changes in skin thickness using a standard scoring system.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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EncompaSSc site in Baltimore, MD
RECRUITINGBaltimore, Maryland, 21224, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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EncompaSSc site in Boston, MA
RECRUITINGBoston, Massachusetts, 02118, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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EncompaSSc site in Clearwater, FL 33765
RECRUITINGClearwater, Florida, 33765, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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EncompaSSc site in Newport Beach, CA 92663
RECRUITINGNewport Beach, California, 92663, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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EncompaSSc site in Tampa, FL
RECRUITINGTampa, Florida, 33606, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.