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New drug MT-2990 aims to ease endometriosis pain in small trial

NCT ID NCT03840993

Symptom relief Sponsor: Tanabe Pharma America, Inc. Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a drug called MT-2990 in 76 women with surgically diagnosed endometriosis and moderate to severe pelvic pain. Participants received either the drug or a placebo over 16 weeks. The goal was to see if MT-2990 safely reduces pain, including non-menstrual pelvic pain, period pain, and pain during sex.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
MT-2990
What this could lead to
If it works, this could point toward a new treatment option for endometriosis-related pain.
What could go wrong
This is an early Phase 2 trial with only 76 participants, so results may not apply to everyone. The drug may not reduce pain better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

76 people

The number who actually took part.

Started

Jan 2019

Finished

Oct 2021

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 49 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Provide written informed consent to participate in this study * Agree to approximately 30-90 day washout interval of hormonal therapies, if applicable * Have a history of regular menstrual cycles * Have a body mass index \< 45 kg/m\^2 (inclusive) * Have documented surgical/laparoscopy diagnosis of endometriosis with 10 years * Agree to use 2 forms of nonhormonal contraception throughout the study * In the Investigator's opinion, subject is able to understand the nature of the study and any risk involved in participation, and is willing to cooperate and comply with the protocol restrictions and requirements including transvaginal ultrasound. * Have moderate to severe endometrial related pain Exclusion Criteria: * Subject is pregnant, breast feeding, or planning a pregnancy. * Subject is \< 6 months postpartum, postabortion, or post-pregnancy. * Willing to remove a hormonal intrauterine device (IUD) at least 30 days prior to screening. (Non hormonal IUDs do not have to be removed) * Aspartate aminotransferase (AST), alanine aminotransferase (ALT) , or total bilirubin ≥ 2.0 × upper limit of normal (ULN) above the reference range * Have immunosuppression due to underlying medical condition * Corrected QT interval using Fridericia's formula (QTcF) or Corrected QT interval using Bazett's formula (QTcB) ≥ 450 msec or clinically important abnormal findings on the ECG * Subject is not up-to-date on breast screening according to current guidelines. * Has a surgical history of hysterectomy, bilateral oophorectomy and any other recent major surgery * Subject is required more than 2 weeks of continuous use of prohibited long-acting narcotic or immediate release narcotic for treatment of endometriosis-associated pain. * Have chronic pelvic pain for nonendometriosis related causes, which require systemic pharmaceutical chronic therapy for pain * Have other chronic pain syndrome which require chronic analgesic or other chronic therapy * Have a clinically significant gynecologic condition identified on the transvaginal ultrasound (TVU) (e.g., complex ovarian cyst \> 3 cm or simple ovarian cyst \> 5 cm, clinically significant endometrial pathology, single fibroid ≥ 4 cm or multiple (\> 4) fibroids that measure ≥ 2 cm or symptomatic submucosal fibroid of any size * Have a current history of undiagnosed abnormal genital bleeding

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Conditions

The condition(s) this trial relates to.

endometriosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Endometrial related pain

Contacts and locations

Locations

  • AGA Clinical Trials

    Hialeah, Florida, 33012, United States

  • Advanced Clinical Research - Idaho

    Meridian, Idaho, 83642, United States

  • Advanced Medical Research Institute

    Miami, Florida, 33174, United States

  • Ageless and Beautiful Medical Spa

    San Diego, California, 92103, United States

  • Agile Clinical Research Trials

    Alpharetta, Georgia, 30005, United States

  • Albuquerque Clinical Trials

    Albuquerque, New Mexico, 87102, United States

  • Altus Research

    Lake Worth, Florida, 33461, United States

  • American Research Centers of Florida

    Pembroke Pines, Florida, 33027, United States

  • Aventive Research - Colombus

    Columbus, Ohio, 43213, United States

  • Axcess Medical Research

    Loxahatchee Groves, Florida, 33470, United States

  • Biopharma Informatic - Houston

    Houston, Texas, 77084, United States

  • Carolina Women's Research and Wellness Clinic

    Durham, North Carolina, 27713, United States

  • ClinEdge - Fusion Clinical Research of Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Clinical Physiology Associates - Fort Myers

    Fort Myers, Florida, 33912, United States

  • Clinical Research Prime

    Idaho Falls, Idaho, 83404, United States

  • Clinical Trial Network

    Houston, Texas, 77074, United States

  • Clinical Trials Management - Covington Northshore Office

    Covington, Louisiana, 70433, United States

  • Continental Clinical Solutions

    Towson, Maryland, 21204, United States

  • Discovery Clinical Trials

    San Antonio, Texas, 78258, United States

  • Drug Studies America - Marietta

    Marietta, Georgia, 30060, United States

  • Future Care Solution

    Miami, Florida, 33165, United States

  • GTC Research

    Shawnee Mission, Kansas, 66218, United States

  • Health Research of Hampton Roads

    Newport News, Virginia, 23606, United States

  • Health and Life Research Institute

    Miami, Florida, 33155, United States

  • Ivetmar Medical Group

    Miami, Florida, 33155, United States

  • Kendall South Medical Center

    Hialeah, Florida, 33012, United States

  • Lyndhurst Gynecologic Associates

    Winston-Salem, North Carolina, 27103, United States

  • Manhattan Medical Research

    New York, New York, 10016, United States

  • Medi-Sense

    Atlanta, Georgia, 30363, United States

  • North Star Medical Research

    Middleburg Heights, Ohio, 44130, United States

  • Northern California Research Corporation

    Sacramento, California, 95821, United States

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • NuDirections Clinical Research

    Dunwoody, Georgia, 30338, United States

  • Omni Fertility and Laser Institute

    Shreveport, Louisiana, 71118, United States

  • PMG Research of Rocky Mount

    Rocky Mount, North Carolina, 27804, United States

  • Physician's Research Options (PRO)

    Draper, Utah, 84020, United States

  • Physician's Research Options (PRO)

    Pleasant Grove, Utah, 84062, United States

  • Precision Research Institute

    San Diego, California, 92114, United States

  • Precision Research Institute - Houston

    Houston, Texas, 77036, United States

  • Precision Trials

    Phoenix, Arizona, 85032, United States

  • Rosemark Women Care Specialists

    Idaho Falls, Idaho, 83404, United States

  • Saginaw Valley Medical Research Group/Women's OB-GYN

    Saginaw, Michigan, 48604, United States

  • South Florida Clinical Trials

    Hialeah, Florida, 33016, United States

  • South Florida Research Phase I-IV

    Miami Springs, Florida, 33166, United States

  • Southern Clinical Research Associates

    Metairie, Louisiana, 70001, United States

  • The Advanced Gynecologic Surgery Institute

    Park Ridge, Illinois, 60068, United States

  • The Lundquist Institute at Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • Unified Women's Clinical Research - Raleigh

    Raleigh, North Carolina, 27607, United States

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio, 44106, United States

  • Wake Research Associates

    Chattanooga, Tennessee, 37421, United States

  • Wasatch Clinical Research

    Salt Lake City, Utah, 84107, United States