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New MRI method could replace scalpel for diagnosing head artery disease

NCT ID NCT05865054

Diagnosis Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study is testing whether a special MRI scan can detect inflammation in the arteries that supply blood to the head, brain, and eyes in people with suspected giant cell arteritis (GCA). Researchers will enroll 400 adults aged 50 and older who have new or worsening symptoms and plan to undergo a biopsy or ultrasound for diagnosis. The goal is to see if MRI can accurately identify artery inflammation, potentially offering a less invasive way to diagnose this condition.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnetic Resonance Imaging (MRI) with contrast
What this could lead to
If successful, MRI could become a reliable, non-invasive way to diagnose giant cell arteritis, reducing the need for surgical biopsies.
What could go wrong
This is an observational study, not a treatment trial. MRI may not be accurate enough to replace current diagnostic methods, and results may vary across patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 400 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2020

Expected to finish

Jul 2033

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants will be recruited from the ambulatory clinic, emergency department, or inpatient settings.

Ages

50 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 50 years or older * First presentation of suspected GCA * New or worsening cranial manifestations within 4 weeks of enrollment concerning for active GCA * Elevated CRP greater than 1.0 mg/dl * Plan to undergo temporal artery biopsy or ultrasound for diagnosis Exclusion Criteria: * Contra-indication to receiving MRI including: Implanted medical devices, pacemaker, and metallic foreign fragments inside body/orbits Known gadolinium allergy Women who are pregnant or nursing * Absence of cranial symptoms related to GCA (e.g., only large vessel GCA)

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Conditions

The condition(s) this trial relates to.

Giant Cell Arteritis temporal arteritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Giant cell arteritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    4 sites in 3 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • 3400 Civic Center Blvd

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • Mayo Building and Gonda Building

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • St. Joseph's Healthcare Hamilton

    NOT_YET_RECRUITING

    Hamilton, Ontario, L8G 5E4, Canada

  • University Hospital Wuerzburg

    NOT_YET_RECRUITING

    Würzburg, Würzburg, 97080, Germany

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