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Wolbachia-Infected mosquitoes released to fight dengue, zika, and chikungunya

NCT ID NCT06595745

Prevention Sponsor: Michigan State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early This study
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial tested a method to control mosquito-borne diseases like dengue, Zika, and chikungunya by releasing male Aedes aegypti mosquitoes infected with Wolbachia bacteria. These males mate with wild females, causing their eggs to die, which reduces the mosquito population. The study took place in Merida, Mexico, and involved over 15,000 residents. Unfortunately, the trial was terminated early, so its full impact is unknown.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Wolbachia-infected male Aedes aegypti mosquitoes
What this could lead to
If successful, this approach could provide a sustainable, chemical-free way to reduce or eliminate mosquito-borne diseases like dengue, Zika, and chikungunya in affected regions.
What could go wrong
The trial was terminated, so results are incomplete. Effectiveness in real-world settings remains unproven, and scaling up may face logistical or ecological challenges.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

15,243 people

The number who actually took part.

Started

May 2024

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * All residents in the release sites will be included in the studies Exclusion Criteria: * No exclusion will be performed.

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Conditions

The condition(s) this trial relates to.

chikungunya prevention target dengue disease prevention target Zika virus infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chikungunya Dengue Zika

Contacts and locations

Locations

  • Laboratorio para el Control Biolo´gico de Aedes aegypti (LCB-UADY), Universidad Autónoma de Yucatán

    Mérida, Yucatán, 97160, Mexico

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