Simple quiz may reveal hidden brain struggles in sickle cell patients
NCT ID NCT05347043
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at whether the Montreal Cognitive Assessment (MoCA), a short test, can accurately screen for thinking and memory problems in adults with sickle cell disease. Researchers compared MoCA results to a full set of standard cognitive tests in 65 adults. The goal is to find a faster way to identify patients who need further evaluation.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could provide a quick, simple screening tool to detect cognitive problems in adults with sickle cell disease, enabling earlier support.
- What could go wrong
- This is a small, completed study (65 people) that only tests the screening tool's accuracy, not a treatment. The MoCA may not catch all cognitive issues, and results may not apply to everyone with sickle cell disease.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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65 people
The number who actually took part.
- Started
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Oct 2022
- Finished
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Oct 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Sickle cell disease, SS or SBêta0 subtypes only * Attending a consultation or a daycare hospitalization in the Tenon hospital sickle cell center * Aged 18 years old or more * Providing written informed consent * With Health Insurance Exclusion Criteria: * Obvious cognitive impairment of neurologic (e.g. previous stroke) or psychiatric origin (e.g. psychotic disorder with negative symptoms) * Insufficient French language fluency to understand the tests, inability to read and write or with no schooling beyond primary school * Anticipated unavailability in the next 6 months * Patients under supervision \& guardianship
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Internal Medicine Department - Tenon
Paris, 75020, France
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