Mindfulness meets Brain-Tech: new study targets repetitive negative thinking in teens
NCT ID NCT06901232
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether combining mindfulness practice with real-time brain feedback can reduce repetitive negative thinking in 90 adolescents aged 14-21 who are at risk for serious mental illness. Participants will undergo mindfulness training with either active or sham neurofeedback, followed by three months of practice and monitoring. The goal is to see if this approach improves thinking patterns and daily functioning.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 90 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2027
An estimate. Start dates often move.
- Expected to finish
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Apr 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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14 to 21 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ages 14-21, inclusive * Recurrent negative thinking, defined as PTQ-C (\<18 years) or PTQ (18 years or older) total score \>30 and at least two questions scored 3 or 4. * Able to understand study procedures, read, and write in English * If age is 18 years or older: Competent and willing to provide written informed consent * If age is less than 18 years: Competent and willing to provide written informed assent AND have a parent/legal guardian who is competent and willing to provide written informed consent * Access to a mobile device to complete daily survey assessments Exclusion Criteria: * Any of the following lifetime mental health disorders by DSM-V criteria: psychotic disorders, anxiety disorder, bipolar disorder, oppositional defiant disorder, conduct disorder, developmental disorder (e.g., autism), post-traumatic stress disorder, or eating disorder * Substance use disorder, moderate or severe in past six months. * Unstable medical or neurologic condition, epilepsy or seizure disorder, head injury, loss of consciousness \>5 minutes * MRI contraindications (i.e. presence of ferromagnetic implants, cardiac pacemaker or pacemaker wires, metallic particles in the body, vascular clips in the head or previous neurosurgery, prosthetic heart valves, magnetic dental implants claustrophobia). * Visual, auditory, or cognitive impairment (IQ\<80 based on the Wechsler Abbreviated Intelligence Scale (WASI)) that may make it difficult to participate. * Any condition or situation that would, in the investigator's opinion, make it unlikely that the participant could adhere safely to the study protocol. * Pregnancy; a negative pregnancy test is required at enrollment * Individuals who are under the legal protection of the government or state (Wards of the State) * Inability to speak, read, or write English fluently
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The places running it
1 site. The list below names each one and where it is.
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The official record
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A doctor treating you
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Contacts and locations
Locations
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Massachusetts General Hospital, Center for Addiction Medicine, 101 Merrimac Street, Suite 320, Boston, MA 02114
Boston, Massachusetts, 02114, United States
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