Not drinking enough water? study reveals hidden effects on aging bodies
NCT ID NCT07084675
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at how mild dehydration (losing 2-3% of body weight through water) and then rehydrating affects inflammation, blood sugar, sleep, and strength in adults aged 45-65. Fifteen healthy participants will follow a 12-day hydration schedule, with five lab visits to measure changes. The goal is to understand if staying hydrated can reduce cellular stress and improve overall health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hydration-Dehydration-Rehydration Protocol (behavioral intervention)
- What this could lead to
- If successful, this study could show that staying well-hydrated helps reduce inflammation and improve physical performance in middle-aged and older adults.
- What could go wrong
- This is a very small early-stage study with only 15 participants, so results may not apply to everyone. It also involves deliberate dehydration, which could cause discomfort or minor health risks.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 15 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2025
- Expected to finish
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Dec 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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45 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Apparently Healthy * BMI \< 30 kg/m2 * Body weight is at least 110 lbs Exclusion Criteria: * Currently pregnant * Have Type 1 Diabetes or Type 2 Diabetes * Have chronic kidney disease or a history of kidney stones * Have hypertension * Take medications that can cause fluid retention, such as corticosteroids, chronic use of Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Hormonal Therapies (e.g., estrogen, androgens or anabolic steroids), Antihypertensives, Psychiatric Medications (e.g., Lithium), Vasodilators * Take medications that reduce fluid retention: diuretics, and RAAS Inhibitors (e.g., ACE inhibitors and ARBs)
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Texas Tech University
RECRUITINGLubbock, Texas, 79409, United States
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