Could a common sedative stop post-surgery nausea?

NCT ID NCT07668700

Symptom relief Sponsor: Hameed Latif Hospital, Lahore Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a low dose of midazolam (a sedative) to the usual two-drug combination (dexamethasone and ondansetron) could better prevent nausea and vomiting after gynecologic laparoscopic surgery. 300 women aged 19–65 took part. Half received the standard two drugs plus a placebo, and the other half received the standard two drugs plus midazolam. The main goal was to see if fewer patients had significant nausea (score under 4 on a 0–10 scale) in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: midazolam
What this could lead to: If it works, this could offer a better way to prevent nausea and vomiting after surgery, improving patient comfort and recovery.
What could go wrong: This is a small, single-center Phase 2 trial. The benefit may be modest, and midazolam can cause drowsiness or other side effects.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

300 people

The number who actually took part.

Started

Dec 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged between 19 to 65 years with an American society of Anesthesiologists (ASA) physical status of \< III. * Patients planned for elective gynecologic laparoscopic procedures' * Female patients. Exclusion Criteria: * Patients with a history of anticancer chemotherapy, alcohol or drug abuse, chronic opioid use, antiemetic intake within 24 hours prior to laparoscopy, or allergy to study drugs. * Hepatic impairment (liver enzymes \>2 times normal value) or renal insufficiency (serum creatinine \>1.6 mg/dl). * Conversion of laparoscopic procedure to laparotomy. * Pregnancy or breastfeeding (childbearing or lactating women). * Borderline QTc prolongation (\>450 ms). * Patients with history of diabetes mellitus, infectious diseases, gastritis, or gastric ulcer. * Body mass index \>35 kg/m². * Patients unable to reliably assess PONV or pain scores.

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Conditions

The condition(s) this trial relates to.

Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anesthesia complications Gynecological laparoscopic surgery Postoperative nausea and vomiting (PONV)

Could a common sedative stop post-surgery nausea?

What the study statuses mean