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A blood test for sleep apnea? MicroRNAs may hold the key

NCT ID NCT06189755

Diagnosis Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 03, 2026 · Last updated Aug 04, 2026 · Updated 1 time

Summary

This study investigates whether tiny molecules in the blood, called microRNAs, can serve as biomarkers for obstructive sleep apnea (OSA). Researchers will compare blood samples from people with moderate-to-severe OSA and those without the condition, before and after treatment with positive airway pressure (PAP) therapy. The goal is to develop a blood test that can identify OSA, reflect treatment effectiveness, and predict blood pressure response.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Positive Airway Pressure (PAP) therapy
What this could lead to
If successful, this could lead to a simple blood test to diagnose sleep apnea and predict who will benefit most from treatment.
What could go wrong
The study is still in early stages, and the biomarkers may not prove accurate or specific enough for clinical use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 500 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2024

Expected to finish

Apr 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants who had a clinical sleep study who meet inclusion criteria for age and AHI and none of the exclusion criteria will be identified using the sleep center databases and electronic medical records. The investigators will also recruit participants from the community- these participants will undergo home sleep study with EEG. The investigators will make a conscious effort to recruit from all ethnic and social economic backgrounds.

Ages

18 to 75 years

Sex

Anyone

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for Cases: * age 18-75 years * moderate-severe OSA (defined as AHI ≥15 events/hour) * willing to accept PAP therapy Inclusion Criteria for Controls: * age 18-75 years * no OSA (defined as AHI \<5 events/hour) Exclusion Criteria for Cases: * current use of PAP or other OSA treatments * home oxygen therapy * recent changes (within 3 months) to BP medications among those who are on these medications * presence of Cheyne-Stokes Respiration (CSR) in sleep study * predominantly central sleep apnea (AHI≥15 events/hour, with \>50% central events) * pregnancy * clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant * organ transplantation * self-reported sleep duration less than 5 hours per night on weeknights (work nights) * current night shift work Exclusion Criteria for Controls: * home oxygen therapy * pregnancy * clinical history of chronic kidney disease (Stage 5) requiring dialysis, or renal transplant * organ transplantation * self-reported sleep duration less than 5 hours per night on weeknights (work nights) * current night shift work

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Conditions

The condition(s) this trial relates to.

obstructive sleep apnea syndrome sleep apnea syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obstructive sleep apnea

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites in 2 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The Ohio State University - Martha Morehouse Medical Pavilion, Suite 2600

    RECRUITING

    Columbus, Ohio, 43221, United States

  • University of Iceland

    RECRUITING

    Reykjavik, Iceland

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

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