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Gum regrowth showdown: microneedling with PRF vs hyaluronic acid

NCT ID NCT07280507

Disease control Sponsor: King Abdulaziz University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This small early trial tests whether microneedling combined with a patient's own platelet-rich fibrin (i-PRF) can rebuild lost gum tissue between teeth better than hyaluronic acid gel injections. Seven adults with mild gum recession are being studied. The goal is to find a less invasive alternative to surgery for improving gum appearance.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Injectable Platelet Rich Fibrin (i-PRF) and Hyaluronic Acid gel
What this could lead to
If it works, this could offer a minimally invasive, biologically active alternative to surgery for restoring gum tissue between teeth.
What could go wrong
This is a very early, tiny trial (only 7 people) testing a cosmetic dental procedure. Results may not apply to everyone, and the approach may not prove better than existing options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Early phase 1

The earliest testing in people: a first look at safety, in a very small group.

Participants

About 7 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Plaque index \<1 * Gingival index \<1 * Class I papillary loss (Nordland and Tarnow classification) * Probing depth ≤4 mm at the test site * Inter-proximal bone crest distance ≤7 mm from the contact point. Exclusion Criteria: * Pregnancy * Lactation * Uncontrolled systemic diseases (e.g., diabetes) * Anticoagulant therapy * Recent radiotherapy * Orthodontic treatment * Midline diastema * High frenum attachment * Class II/III papillary loss.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Papilla reconstruction

Contacts and locations

Locations

  • King AbdulAziz University

    Jeddah, Saudi Arabia

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