Gum regrowth showdown: microneedling with PRF vs hyaluronic acid
NCT ID NCT07280507
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This small early trial tests whether microneedling combined with a patient's own platelet-rich fibrin (i-PRF) can rebuild lost gum tissue between teeth better than hyaluronic acid gel injections. Seven adults with mild gum recession are being studied. The goal is to find a less invasive alternative to surgery for improving gum appearance.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Injectable Platelet Rich Fibrin (i-PRF) and Hyaluronic Acid gel
- What this could lead to
- If it works, this could offer a minimally invasive, biologically active alternative to surgery for restoring gum tissue between teeth.
- What could go wrong
- This is a very early, tiny trial (only 7 people) testing a cosmetic dental procedure. Results may not apply to everyone, and the approach may not prove better than existing options.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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King AbdulAziz University
Jeddah, Saudi Arabia
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