Gum regrowth showdown: microneedling with PRF vs hyaluronic acid
NCT ID NCT07280507
First seen Dec 18, 2025 · Last updated Jun 19, 2026 · Updated 25 times
Summary
This small early trial tests whether microneedling combined with a patient's own platelet-rich fibrin (i-PRF) can rebuild lost gum tissue between teeth better than hyaluronic acid gel injections. Seven adults with mild gum recession are being studied. The goal is to find a less invasive alternative to surgery for improving gum appearance.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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King AbdulAziz University
Jeddah, Saudi Arabia
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Injectable Platelet Rich Fibrin (i-PRF) and Hyaluronic Acid gel
What this could lead to
If it works, this could offer a minimally invasive, biologically active alternative to surgery for restoring gum tissue between teeth.
What could go wrong
This is a very early, tiny trial (only 7 people) testing a cosmetic dental procedure. Results may not apply to everyone, and the approach may not prove better than existing options.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.