Can microneedling plus creams fade red stretch marks? new trial aims to find out
NCT ID NCT07154030
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This early-stage trial tests whether microneedling combined with either tretinoin 0.025% or timolol 0.5% can improve the appearance of red stretch marks (stria rubra). Researchers will enroll 300 adults and track changes through photos and skin checks. The goal is to see if these combinations work better than microneedling alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- microneedling with tretinoin 0.025% or timolol 0.5%
- What this could lead to
- If successful, this could offer a more effective way to reduce the appearance of red stretch marks.
- What could go wrong
- This is a very early Phase 1 trial, so results are uncertain. The treatments may not work better than existing options, and side effects like irritation or scarring are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1
The first testing in people. Mainly checks safety and dose, usually in a small group.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2025
An estimate. Start dates often move.
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * The study will include patients with stria rubra aged ≥18 Exclusion Criteria: \- 1.Pregnant \& lactating patients. 2.Patients with bleeding disorders or on anticoagulant therapy. 3.Patients using drugs that exacerbate the striae as systemic corticosteroids in the preceding two months or topical corticosteroid in the preceding one month. 4.Patients having active infection at the treatment area. 5.Patients with keloidal tendency. 6.Patients using other forms of treatment for stria as emollients, glycolic acid peel and laser over the last 2 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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