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Gut bacteria tweak may curb weight regain

NCT ID NCT06681246

Knowledge-focused Sponsor: Weizmann Institute of Science Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 12, 2026 · Updated 2 times

Summary

This study explores whether changing gut bacteria with antibiotics can help people keep weight off after losing at least 10% of their body weight. 200 adults with a BMI between 28 and 35 will take either antibiotics or a placebo for 10 days. Researchers will track weight, microbiome changes, and blood sugar responses to see if this approach could prevent the common cycle of weight regain.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Antibiotics (Augmentin) or placebo
What this could lead to
If it works, this could point toward a new way to prevent weight regain after dieting by targeting gut bacteria.
What could go wrong
This is an early exploratory study, not a treatment trial. Antibiotics can have side effects and may not prevent weight regain. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 28 \< BMI\< 40 * Age - 18-65 * Capable of working with a smartphone application Exclusion Criteria: * Consumption of antibiotics/probiotics/oral antifungals 2 months prior to the first day of the experiment. * Pregnancy, fertility treatments, breastfeeding women six months prior to enrollment and during the study. * Chronic disease, to the discretion of the study team (e.g. AIDS, Cushing syndrome, CKD, acromegaly etc.) * Cancer and recent anticancer treatment * Psychiatric disorders, to the discretion of the study team. * Coagulation disorders * IBD (inflammatory bowel diseases) * Bariatric surgery. * Eating disorders (Anorexia nervosa. Bulimia nervosa. Binge eating disorder, Night eating syndrome). * Alcohol or substance abuse * Weight loss attempts 6 months prior to the first day of the experiment - using weight loss medication. * Drastic changes in nutritional habits six months prior to the first day of the study - to the discretion of the study team. * Allergy to penicillin. * Life threatening reaction after consumption of cephalosporins. * History of CDI * Liver disease * History of serious unresolved diarrhea in response to antibiotic treatment to the discretion of the study doctor.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Weight Loss

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Weight loss

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Weizmann Institute of Science

    RECRUITING

    Rehovot, Israel

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