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Timing of sperm extraction may influence IVF live birth rates

NCT ID NCT07268235

Knowledge-focused Sponsor: Clinique Ovo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 129 men with low or no sperm in their semen who had sperm surgically removed from the testicle (micro-TESE) for IVF. Researchers compared doing the sperm retrieval 24 hours versus 48 hours before the egg retrieval to see if timing affected live birth rates. The goal is to find the best schedule for couples undergoing fertility treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If timing matters, it could help doctors plan IVF procedures to improve chances of live birth for couples with male infertility.
What could go wrong
This is a small, retrospective study (129 participants) from a single clinic, so results may not apply to everyone. It only looks at timing, not a new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

129 people

The number who actually took part.

Started

Nov 2025

Finished

Nov 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Men who underwent a micro-TESE for IVF treatment

Ages

18 years and older

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Men who underwent a micro-TESE at the OVO clinic from June 2015 to January 2025. * Patients with non-obstructive azoospermia (NOA), (absence of spermatozoa in multiple semen analyses) * Patients with cryptozoospermia, (presence of a small number of spermatozoa detectable only after semen centrifugation) * Patients with oligoasthenoteratozoospermia (OAT), (sperm concentration of less than 15 million/mL, reduced motility and abnormal morphology) Exclusion Criteria: * Patients who did not have any sperm noted following micro-TESE * Use of donor sperm or oocytes * Frozen sperm or oocytes * Same day oocyte retrieval and sperm extraction * Reversible cause of cryptozoospermia (i.e presence of a varicocele, febrile illness, or recent toxin exposure) Partial genital tract obstruction (i.e post-vaso-vasostomy, post-vasoepididymostomy, and low volume cryptozoospermia with ejaculatory duct obstruction)

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Conditions

The condition(s) this trial relates to.

azoospermia oligoasthenoteratozoospermia oligospermia spermatogenic failure 3

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Microdissection testicular sperm extraction

Contacts and locations

Locations

  • Clinique ovo

    Montreal, Quebec, H4P 2S4, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.