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Shocking ACL recovery: electric pulses and eccentric lifts show promise

NCT ID NCT03626857

Disease control Sponsor: University of Michigan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding neuromuscular electrical stimulation (NMES) and eccentric leg press exercises to standard rehabilitation can help people regain muscle strength and protect knee cartilage after anterior cruciate ligament (ACL) reconstruction. 135 participants who had ACL surgery were assigned to different rehab combinations. The goal was to see if these extra therapies improve muscle function and potentially lower the risk of future knee osteoarthritis.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Neuromuscular electrical stimulation (NMES) device and eccentric leg press exercise
What this could lead to
If successful, this approach could improve muscle recovery and reduce the risk of post-traumatic knee osteoarthritis after ACL reconstruction.
What could go wrong
This is a completed early-stage study with 135 participants, so results may not apply to everyone. The interventions are add-ons to standard rehab, not a standalone cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

135 people

The number who actually took part.

Started

Feb 2019

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

14 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Acute, complete ACL rupture * ACL reconstruction with autograft * Scheduled to undergo ACLR at U of Michigan * Willingness to participate in testing and follow-up as outlined Exclusion Criteria: * Previous surgery to either knee * Bony fracture accompanying ACL injury * Patients who experienced a knee dislocation * Female participants who are pregnant or planning pregnancy

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injury

Contacts and locations

Locations

  • MedSport

    Ann Arbor, Michigan, 48109, United States

  • University of Michigan

    Ann Arbor, Michigan, 48109, United States

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