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Can a heart drug make surgery safer? new trial investigates

NCT ID NCT07597564

Symptom relief Sponsor: Fujian Provincial Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether combining two drugs, metoprolol and sufentanil, can prevent sudden spikes in heart rate and blood pressure when a breathing tube is placed during general anesthesia. 900 adults having non-cardiac surgery will receive different dose combinations. The goal is to find the best balance for a smoother, safer intubation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
metoprolol and sufentanil
What this could lead to
If successful, this could lead to a safer, more stable way to manage heart rate and blood pressure during breathing tube insertion for surgery.
What could go wrong
This is a phase 4 trial focused on short-term stability during a routine procedure, not a cure or major breakthrough. Results may not apply to patients with heart or lung conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 900 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jun 2026

An estimate. Start dates often move.

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 to 65 years. * American Society of Anesthesiologists physical status I or II. * Scheduled for elective non-cardiac surgery. * Planned general anaesthesia with endotracheal intubation. Exclusion Criteria: * Cardiovascular or respiratory diseases, such as uncontrolled hypertension or bronchial asthma. * Current use of β-blockers. * History of chronic drug use or alcohol abuse. * Hepatic or renal impairment. * Known allergy to any study drug. * Anticipated difficult airway. * Any other condition that may affect the conduct of the study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

General anesthesia; tracheal intubation Hemodynamic response to tracheal intubation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Fujian provincial hospital

    Fuzhou, Fujian, 350000, China

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