New inhaler could ease tooth pain in minutes
NCT ID NCT06495372
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether methoxyflurane (Penthrox®), a painkiller inhaled through a handheld device, can quickly reduce moderate to severe dental pain in adults. 190 participants in a dental emergency department received either methoxyflurane or a placebo alongside standard care. The main goal was to see if pain dropped within 15 minutes, offering a fast relief option while waiting for a dentist.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- methoxyflurane (Penthrox®)
- What this could lead to
- If it works, this could provide a fast, effective painkiller for people with severe dental pain while they wait for a dentist.
- What could go wrong
- This is a completed Phase 3 trial, but the results are not yet published. Methoxyflurane may cause side effects like drowsiness or nausea, and it may not work better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
-
190 people
The number who actually took part.
- Started
-
Oct 2024
- Finished
-
Oct 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adult patient (\> 18 years) * Conscious patient consulting an oral emergency department with pain assessed as moderate to severe NRS greater than or equal to 4 * Patient has social security affiliation or who beneficiary of such social security * Patients who have given informed consent Exclusion Criteria: * Patients with a history of allergy to methoxyflurane or any of the components of Penthrox (take into account family history of severe allergic reactions) * Patients with a history of malignant hyperthermia (known or genetic predisposition) * Patients with hepatic impairment after use of methoxyflurane or halogenated hydrocarbon anesthesia * Patients with severe renal Failure * Patients with altered level of consciousness, whatever the cause: head trauma, drug or alcohol abuse * Patients with cardiovascular instability or respiratory depression * Pregnant or breast-feeding patients. Therefore, a urine pregnancy test will be performed for all patients of childbearing age eligible to participate in the study * Patients under legal protection (guardianship and curatorship) or deprived of liberty * Patients unable to speak or read French fluently, unable to understand the principle of a numerical scale, anxiety and satisfaction questionnaires, and unable to cooperate with tests
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Brest
Brest, 29200, France
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Other studies related to the condition(s) this trial covers.