Psoriasis combo therapy trial: does methotrexate boost Anti-TNF?

This study looked at whether adding low-dose methotrexate to standard anti-TNF therapy helps adults with moderate to severe psoriasis achieve and maintain better skin clearance. About 78 participants who had not used anti-TNF drugs before were randomly assigned to receive either methotrexate or a placebo alongside their anti-TNF treatment. The goal was to see if the combination could prevent loss of response over 24 months. The study was terminated early, so results are limited.