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New DNA blood test could speed up heart infection diagnosis

NCT ID NCT06309680

Diagnosis Sponsor: Queen Mary University of London Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new blood test that looks for bacterial DNA to quickly identify the germ causing infective endocarditis, a serious heart valve infection. Current methods take up to 5 days, delaying the right antibiotics. The study will enroll 200 adults with suspected endocarditis and compare the new test's accuracy to standard blood cultures.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 200 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2023

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The sample will be a consecutive group of patients from hospitals in the trial referred to BHC Endocarditis MDT meeting for management of their disease. Approximately 150 cases are referred to the Endocarditis MDT each year and we reject the diagnosis of endocarditis in 17% of patients by the time of discharge (the cases are highly selected by the time they are referred). The study is designed to be practicable and applicable to a real-world group of patients. Thus, we will study all patients who give consent and have possible or definite endocarditis as per the determination of the clinical Endocarditis MDT. In practice, by the time treatment is completed the number left in the possible endocarditis group is very small (\<5%) although when the patient is first referred approximately 20% are in that category. As the disease progresses down its course, the correct diagnosis quickly becomes apparent - especially after surgery.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with possible or confirmed IE referred to BHC Endocarditis MDT * Age \>18 * Able and willing to give informed consent Exclusion Criteria: * Patients whose diagnosis of endocarditis is "rejected" by the MDT. If this occurs after entry to the study samples will be discarded and the patient informed. * Patients who have been treated with intravenous antibiotics for more than 7 days at the time of study entry.

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Conditions

The condition(s) this trial relates to.

endocarditis infective endocarditis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Infective endocarditis

Contacts and locations

Locations

  • St Bartholomew's Hospital. West Smithfield

    London, EC1A 7BE, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.