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Menthol vs. tobacco: which E-Cig helps smokers quit regular cigarettes?

NCT ID NCT05555069

Disease control Sponsor: Nikki Nollen, PhD, MA Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares menthol-flavored and tobacco-flavored e-cigarettes to see which helps adult menthol smokers switch from regular cigarettes. 800 participants who smoke at least 5 menthol cigarettes daily will use the assigned e-cigarette for 12 weeks. The main goal is to see how many completely switch to e-cigarettes by week 12.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Menthol-flavored electronic cigarette
What this could lead to
If successful, this could show that menthol-flavored e-cigarettes are a more effective tool to help menthol smokers switch away from combustible cigarettes.
What could go wrong
This is a behavioral study, not a treatment trial. Results may not apply to all smokers, and switching to e-cigarettes still carries health risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2022

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ≥ 21 years of age * Smoke ≥ 5 cigarettes per day (CPD) * Smoke menthol cigarettes for ≥ 6 months * Verified smoker (CO \>5ppm) * Functioning telephone * Interested in switching to E-cigarettes Exclusion Criteria: * Interested in quitting smoking * Use of other tobacco products in past 30 days (i.e. cigarillos, cigars, hookah, smokeless tobacco, pipes) * E-cigarette use on ≥ 4 of the past 30 days * Uncontrolled hypertension: BP ≥ 180(systolic) or ≥ 105 (diastolic) * Use of smoking cessation pharmacotherapy in the month prior to enrollment * Pregnant, contemplating getting pregnant, or breastfeeding * Plans to move from Kansas City during the treatment and follow-up phase * Another household member enrolled in the study

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Conditions

The condition(s) this trial relates to.

Smoking Reduction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Smoking reduction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Kansas Medical Center

    RECRUITING

    Kansas City, Missouri, 64130, United States

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