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Melatonin plus sevoflurane may offer safer MRI sedation for young kids

NCT ID NCT06606899

Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two ways to sedate preschool children (ages 2-5) for brain MRI scans. One group received oral melatonin and nasal sevoflurane; the other got oral chloral hydrate and nasal sevoflurane. The goal was to see which combination worked better and more safely. The trial involved 60 children and has already been completed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Melatonin and chloral hydrate (sedatives)
What this could lead to
If successful, this could point toward a safer, more effective sedation option for young children undergoing MRI scans.
What could go wrong
This is a small, completed trial with only 60 participants, so results may not apply to all children. The primary outcome was assessed post-hoc, which reduces reliability.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

60 people

The number who actually took part.

Started

Sep 2024

Finished

Dec 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 5 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients American Society of anesthesiologists' physical status (ASA) I to II. 2. Aged 2 to 5 years. 3. Both sexes. 4. Patients scheduled for Brain MRI. Exclusion Criteria: 1. Parent refusal. 2. ASA physical status III or more. 3. Patients with known allergy to any of the study drugs. 4. Children with COSA. 5. Patients with history of cardiovascular disease. 6. Patients older than 5 years. 7. Patients with neuromuscular disease. 8. Patients younger than 2 years. 9. Patients suffering from respiratory tract infection. 10. Patients with family history of malignant hyperthermia. 11. Patients with any Musculoskeletal disorder.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Sedation for children undergoing mri

Contacts and locations

Locations

  • Ain shams university hospitals

    Cairo, Egypt