Melatonin plus sevoflurane may offer safer MRI sedation for young kids
NCT ID NCT06606899
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 42 times
Summary
This study tested two ways to sedate preschool children (ages 2-5) for brain MRI scans. One group received oral melatonin and nasal sevoflurane; the other got oral chloral hydrate and nasal sevoflurane. The goal was to see which combination worked better and more safely. The trial involved 60 children and has already been completed.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Ain shams university hospitals
Cairo, Egypt
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Melatonin and chloral hydrate (sedatives)
What this could lead to
If successful, this could point toward a safer, more effective sedation option for young children undergoing MRI scans.
What could go wrong
This is a small, completed trial with only 60 participants, so results may not apply to all children. The primary outcome was assessed post-hoc, which reduces reliability.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.