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Melatonin may take the edge off mental stress, small trial suggests

NCT ID NCT07138443

Symptom relief Sponsor: Baylor University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study tests whether a single 3mg dose of melatonin, a common sleep supplement, can reduce the body's physical reactions to mental stress. Healthy adults aged 18-70 will take either melatonin or a placebo before a stressful public-speaking task. Researchers will measure changes in heart rate, blood pressure, and skin temperature to see if melatonin helps keep these responses in check.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 3mg oral melatonin tablet
What this could lead to
If it works, this could point toward a simple, over-the-counter way to dampen the body's physical stress response.
What could go wrong
This is a very small, early-stage trial with only 16 people, so results may not apply broadly. Melatonin can cause drowsiness, and its effects on stress are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Aug 2025

Finished

Jul 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Must be between the ages of 18-70 years old. * All subjects will be required to abstain from exercise and caffeine for 12 h, and alcohol for 24 h prior to the experiment. * BMI must be \<30 kg/m2. * Menstruating women will initially be tested during their early follicular phase (2-5 days after initiating menstruation) or during low hormone phase (2-5 days after initiating menstruation) if on oral contraceptives to control for potential impact of sex steroids. Post-menopausal females (\>5 years) will also be included. Females must have an intact uterus and at least one ovary. Use of hormonal replacement therapy will be allowed. Exclusion Criteria: * Circadian rhythm sleep disorders * High obstructive sleep apnea diagnosis determined by STOP-BANG. * History of meeting Diagnostic and Statistical Manual of Mental health (DSM-V) criteria of major psychiatric disorder * Unstable or serious medical conditions (heart failure, diabetes, cardiovascular disease, etc.) * Current, or use within past month, of psychoactive (other than stable treatment with antidepressant), hypnotic, stimulant or analgesic medication (except occasional non-narcotic analgesics), beta blockers, or alpha blockers * Shift work or other types of self-imposed irregular sleep schedules * Habitual smoking (6 or more cigarettes per week) * Habitual alcohol consumption (more than 2 alcoholic drinks per day) * Pregnancy or breast feeding

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Conditions

The condition(s) this trial relates to.

Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mental stress Stress

Contacts and locations

Locations

  • Baylor University Autonomic Function Laboratory

    Waco, Texas, 76706, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.