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Melatonin may take the edge off mental stress, small trial suggests

NCT ID NCT07138443

Completed Symptom relief Sponsor: Baylor University Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study tests whether a single 3mg dose of melatonin, a common sleep supplement, can reduce the body's physical reactions to mental stress. Healthy adults aged 18-70 will take either melatonin or a placebo before a stressful public-speaking task. Researchers will measure changes in heart rate, blood pressure, and skin temperature to see if melatonin helps keep these responses in check.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
a 3mg oral melatonin tablet
What this could lead to
If it works, this could point toward a simple, over-the-counter way to dampen the body's physical stress response.
What could go wrong
This is a very small, early-stage trial with only 16 people, so results may not apply broadly. Melatonin can cause drowsiness, and its effects on stress are not yet proven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Stress, Psychological

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MENTAL STRESS STRESS

Contacts and locations

Locations

  • Baylor University Autonomic Function Laboratory

    Waco, Texas, 76706, United States

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