Diet and exercise combo may boost bone health in seniors
NCT ID NCT07584785
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether combining a Mediterranean diet with progressive resistance training could improve bone density in adults aged 65 and older. Over 12 months, 22 participants followed the diet and exercise program, while 19 received no structured intervention. Researchers measured bone density and bone turnover markers to see if the lifestyle changes helped maintain or improve bone health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Mediterranean diet and progressive resistance training
- What this could lead to
- If successful, this could point toward a simple lifestyle program to help older adults maintain bone strength and reduce fracture risk.
- What could go wrong
- This is a small, completed trial with only 47 participants. Results may not apply to everyone, and the effect on actual fractures is not measured.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
47 people
The number who actually took part.
- Started
-
Mar 2024
- Finished
-
Mar 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
65 to 90 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults aged 65 years and older * Ability to provide written informed consent * Willingness to comply with study procedures and interventions * Capability to participate in a supervised exercise program Exclusion Criteria: * Presence of metabolic bone diseases (e.g., osteoporosis requiring pharmacological treatment, Paget's disease, osteomalacia) * Use of medications affecting bone metabolism, including systemic corticosteroids, bisphosphonates, hormone replacement therapy, selective estrogen receptor modulators, calcitonin, or parathyroid hormone analogs * Uncontrolled cardiometabolic or respiratory conditions (e.g., uncontrolled hypertension, unstable angina, recent cardiovascular events within 6 months, severe chronic obstructive pulmonary disease, or poorly controlled diabetes) * Severe musculoskeletal disorders or advanced osteoarthritis limiting safe exercise participation * Neurological or psychiatric conditions affecting mobility or adherence * Cognitive impairment (Mini-Mental State Examination score \<24) * Recent fractures or major orthopedic surgery within the past 12 months * Underweight (BMI \<18.5 kg/m²) or severe frailty * Severe renal or hepatic dysfunction (e.g., chronic kidney disease stage 4-5 or liver failure) * Active malignancy or ongoing chemotherapy/radiotherapy * Participation in another clinical trial within the previous 3 months
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Bone health are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Antonella MUSCELLA
Lecce, LE, 73100, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Pregnancy hormone hCG may hold clues to bone and gland health
- Simple scan mistakes may skew osteoporosis diagnoses
- Can better posture strengthen the pelvic floor in osteoporosis?
- Could exercise be the key to stronger bones in women?
- Robotic legs may help rebuild bone in people with spinal cord injury
- Could a simple education program stop the cycle of fractures in the elderly?