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New modular implants aim to rebuild bones lost to cancer or injury

NCT ID NCT07369778

Disease control Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study will test a new line of massive prosthetic implants (the Pantheon range) in 375 people who have lost large amounts of bone due to cancer, complex fractures, or failed previous surgeries. The implants are designed to restore function quickly and stay stable long-term. Researchers will track how long the implants last without needing revision and how patients' quality of life changes over five years.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pantheon range massive prosthetic implants (including PFR, DFR, PTR, TFR, hybrid connectors, custom-made implants)
What this could lead to
If successful, this could confirm that these modular implants provide long-lasting, stable reconstruction for people with severe bone loss, improving mobility and quality of life.
What could go wrong
This is an early-stage observational study with no control group, so results may not prove superiority over existing options. Implants can fail over time, requiring revision surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 375 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

May 2026

An estimate. Start dates often move.

Expected to finish

Jan 2036

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The population concerns patients with massive bone loss, because of oncological or non-oncological issue. Patients have massive prosthetic reconstruction using the Pantheon prosthesis from Adler Laboratories. The prostheses are: * Proximal Femur Recontruction (PFR) * Distal Femur Reconstruction (DFR) * Proximal Tibia Reconstruction (PTR) * Total Femur Reconstruction (TFR) * Custom implants Minors aged 15 and over may be included in the study, with no maximum age limit. Patient who has been informed about the study and doesn't object to participating.

Ages

15 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients aged 15 years or older at the time of inclusion * Surgery scheduled at one of the participating centres with an Adler implant from the list below: Implants from the Pantheon prosthesis: Proximal Femur Recontruction (PFR) Distal Femur Reconstruction (DFR) Proximal Tibia Reconstruction (PTR) Total Femur Reconstruction (TFR) Hybrid connector implants Custom-made implants * Follow-up scheduled at one of the participating centres for the duration of the study * Patient who has been informed about the study and does not object to participating In the case of minor patients, the patient's parents will also be informed, and their non-objection will be sought. * Patient affiliated with a Social Security scheme in France. Exclusion Criteria: * Patient or parent of a minor patient who objects to participation in the study and data collection. * Patient deprived of liberty or under legal protection (guardianship or curatorship)

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Conditions

The condition(s) this trial relates to.

Gorham-Stout disease neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Reconstruction of massive bone loss (oncologic and non-oncologic)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • CHU de Nantes

    Nantes, 44093, France