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Could a simple mineral stop Post-Surgery bladder pain?

NCT ID NCT05806996

Symptom relief Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 29, 2026 · Last updated Aug 14, 2026 · Updated 3 times

Summary

This study tests whether giving magnesium through a vein can prevent or reduce bladder spasms after urologic surgery. About 120 adults having bladder procedures will receive either magnesium or a placebo. Researchers will compare how many people in each group have spasms and how severe they are.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Magnesium (intravenous)
What this could lead to
If effective, magnesium could offer a simple, low-cost option to prevent or reduce painful bladder spasms after urologic surgery.
What could go wrong
This is a small Phase 2 trial, so results may not be conclusive. Magnesium may not work better than placebo, and side effects like low blood pressure or nausea are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

120 people

The number who actually took part.

Started

Jun 2023

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: \- Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center. Exclusion Criteria: * Are unable to grant informed consent or comply with study procedure. * Allergy or known sensitivity to magnesium or Renacidin. * Expected or high risk of bladder extravasation. * Ongoing atrial fibrillation prior to surgery. * Are undergoing emergency surgery. * Are pregnant. * Known hypermagnesemia. * Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect. * Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects. * Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium. * Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bladder spasms

Contacts and locations

Locations

  • Mayo Clinic in Minnesota

    Rochester, Minnesota, 55905, United States