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Could a neck surgery slow Alzheimer's? new trial aims to find out

NCT ID NCT07658430

Disease control Sponsor: Southwest Hospital, China Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a surgical procedure called deep cervical lymphovenous anastomosis (LVA) for people with moderate Alzheimer's disease. The surgery aims to improve the brain's ability to clear waste proteins, like amyloid-beta, which are linked to Alzheimer's. Researchers will compare 148 people who get the surgery plus standard medication against 148 who get only medication, tracking their cognitive function and brain changes over 12 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
deep cervical lymphovenous anastomosis (LVA) surgery
What this could lead to
If successful, this could offer a new surgical option to slow cognitive decline in moderate Alzheimer's by improving the brain's waste-clearing system.
What could go wrong
This is an early-stage surgical trial with no prior efficacy data in Alzheimer's. The procedure carries surgical risks, and the benefit over standard drug treatment is unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 296 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jun 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 50 to 80 years old, male or female. * Clinically diagnosed with moderate probable Alzheimer's disease according to the NIA-AA criteria. * Baseline Mini-Mental State Examination (MMSE) score between 10 and 20 points. * Clinical cognitive decline duration of at least 6 months. * Stable routine anti-dementia drug treatment for more than 6 months without obvious clinical improvement. * Able to complete neuropsychological scale assessments, blood biomarker detection and Aβ-PET examination. * Have a reliable caregiver who can accompany follow-up visits and assist in completing evaluations. * The participant or legal surrogate voluntarily signs the written informed consent. Exclusion Criteria: * Severe cardiac, hepatic, renal, respiratory or hematopoietic system dysfunction unable to tolerate surgery or anesthesia. * A history of intracranial surgery, severe craniocerebral trauma, stroke, brain tumor or other central nervous system diseases. * Other types of dementia, including vascular dementia, frontotemporal dementia, Lewy body dementia, or mixed dementia. * Psychiatric disorders requiring long-term medication that may affect cognitive assessment results. * Contraindications for PET imaging or contrast agent allergy. * Active infection, malignant tumor or severe wasting disease. * Pregnancy or breastfeeding status. * Participation in other interventional clinical trials within 3 months before enrollment. * Poor compliance or inability to complete scheduled follow-up. * Any other condition judged inappropriate for enrollment by the investigator.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alzheimer's disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • The First Affiliated Hospital of Army Medical University (Southwest Hospital)

    Chongqing, Chongqing Municipality, 400038, China

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