Breathing in xenon: a new way to see lung health without X-Rays?
NCT ID NCT02272049
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing a special MRI technique that uses inhaled xenon gas to create detailed images of lung function. Researchers want to see how well it works in healthy children and adults, as well as in people with various breathing problems. Participants will inhale the gas and hold their breath for up to 16 seconds during the scan. The goal is to find a safer, radiation-free way to assess lung health.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hyperpolarized 129 Xenon gas
- What this could lead to
- If successful, this could provide a safer, more detailed way to measure lung function without radiation, helping doctors better diagnose and monitor respiratory diseases.
- What could go wrong
- This is an early-phase study focused on imaging, not treatment. The technique may not prove reliable enough for routine use, and some people may have trouble holding their breath for the scan.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 1/2
Runs two stages together: safety and dose first, then whether the treatment works.
- Participants
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About 300 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2014
- Expected to finish
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Aug 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Ages 6 and up * Participant must be able to hold breath for up to 16 seconds Exclusion Criteria: * History of heart defect * Pregnancy or positive pregnancy test * History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month * Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week * Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula * Participant is claustrophobic and unable to tolerate the imaging. * Standard MRI exclusions (metal, implants)
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Cincinnati Children's Hospital Medical Center
RECRUITINGCincinnati, Ohio, 45229, United States
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