Baking soda could help doctors see lung blood flow in real time
NCT ID NCT07542366
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This pilot study tests whether sodium bicarbonate (baking soda) can be used safely as a contrast agent to map lung blood flow using electrical impedance tomography (EIT) in adults on breathing machines. Researchers will compare it to standard hypertonic saline in 41 ICU patients. The goal is to see if this method produces clear images and is safe, potentially offering a simpler bedside tool for assessing lung function.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- sodium bicarbonate (5%) and hypertonic saline (10%)
- What this could lead to
- If successful, this could provide a safer, cheaper way to assess lung blood flow at the bedside in critically ill patients.
- What could go wrong
- This is a very small pilot study (41 people) testing feasibility, not effectiveness. The contrast agents may not produce clear images, or safety issues could arise.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 41 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2024
- Expected to finish
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Sep 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Critically ill adult patients admitted to a mixed intensive care unit, receiving invasive mechanical ventilation and equipped with a central venous catheter. All participants undergo a single bedside electrical impedance tomography examination with sequential bolus injections of hypertonic saline and 5% sodium bicarbonate for pulmonary perfusion assessment.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age ≥ 18 years * Admitted to the intensive care unit (ICU) * Receiving invasive mechanical ventilation with controlled or assisted-controlled mode * Presence of a central venous catheter suitable for contrast bolus injection * Hemodynamically stable (no ongoing cardiopulmonary resuscitation; no uncontrolled shock judged by treating physician) * Expected to remain on mechanical ventilation for the duration of the EIT examination * Written informed consent obtained from the patient or legally authorized representative Exclusion Criteria: * Known pregnancy * Known allergy, intolerance, or contraindication to sodium bicarbonate or hypertonic saline * Severe arrhythmia or unstable cardiovascular status in which small bolus injection is deemed unsafe by the treating physician * Uncontrolled agitation or conditions that preclude correct EIT belt placement (e.g., extensive chest wounds, large chest dressings, chest wall deformity that prevents belt use) * Implanted electronic devices or metallic implants in the thoracic area considered a contraindication to EIT by the manufacturer's instructions * End-stage disease with expected survival of only a few hours, in whom participation is not appropriate as judged by the treating physician * Participation in another interventional trial that, in the opinion of the investigator, could interfere with EIT measurements or safety assessment
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)
RECRUITINGWuhu, Anhui, 241001, China
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