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MS patients may soon get voice therapy from home

NCT ID NCT05930379

Symptom relief Sponsor: Fondazione Don Carlo Gnocchi Onlus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This pilot study tested whether a voice therapy program called LSVT-Loud, usually done in a clinic, can be delivered effectively via video calls for people with multiple sclerosis (MS). Twenty participants with MS who had voice problems received the therapy either at home or in the clinic. The goal was to see if the at-home approach is feasible and can improve voice loudness during everyday speaking. The study is small and focused on feasibility, so results are preliminary.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
LSVT-Loud voice therapy
What this could lead to
If successful, this could offer a convenient at-home voice therapy option for people with MS who have trouble speaking loudly or clearly.
What could go wrong
This is a very small pilot study (20 people) testing feasibility, not effectiveness. Results may not apply to all MS patients, and telerehab may not work as well as in-person therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jun 2023

Finished

Sep 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * diagnosis of MS according to the criteria of MC Donald 2010 (Polman et al., 2011; Thompson et al., 2018) * perceived voice intensity disability and severity of speech and voice disorder prior to treatment (as judged independently by two speech-language pathologists highly experienced with voice and motor speech disorders) * age ≥ 18; * not treated for hypophonia in the six months before enrollment in the study * with a preserved cognitive level at the Mini-Mental State Examination (MMSE test \>24) (Folstein et al., 1975); * available and able to use a PC with an internet connection at home to access the telerehabilitation sessions; * agreeing to participate with the signature of the informed consent form; * stable drug treatment (last 3 months), if any; * absence of relapses (last month) before taking part in the study. Exclusion Criteria: * presence of dysphonia related to other diseases; * presence of other neurological disorders different from MS; * presence of major psychiatric conditions; * presence of severe impairment of visual and/or acoustic perception; * history of laryngeal cancer, radiotherapy, or head-neck trauma, or intubation.

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Conditions

The condition(s) this trial relates to.

communication disorder multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Multiple sclerosis

Contacts and locations

Locations

  • Fondazione Don Gnocchi ONLUS

    Milan, Italy/Milan, 20148, Italy

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