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A gentler anesthesia cocktail may protect blood pressure during emergency intubation

NCT ID NCT07730918

Disease control Sponsor: Aoyang Hospital Affiliated to Jiangsu University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 28, 2026 · Last updated Jul 29, 2026 · Updated 1 time

Summary

This trial tests whether a lower dose of the sedative propofol combined with a higher dose of the fast-acting opioid alfentanil can keep blood pressure and heart rate more stable during rapid-sequence intubation. About 172 adults having planned surgery will receive one of four drug combinations. The main goal is to see if this approach reduces dangerous drops in blood pressure while still allowing the breathing tube to be placed quickly and safely.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a combination of propofol and alfentanil
What this could lead to
If this approach works, it could point toward a safer way to put people under anesthesia quickly without dangerous drops in blood pressure.
What could go wrong
This is a small, non-randomized study, so results may not apply to all patients. The higher opioid dose could also cause breathing problems or other side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

172 people

The number who actually took part.

Started

Aug 2025

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ASA physical status I or II * Age 18 to 60 years * Body mass index (BMI) 18 to 30 kg/m² * Scheduled for elective surgery at Aoyang Hospital Affiliated to Jiangsu University Exclusion Criteria: * Hypertension, diabetes mellitus, or cardiopulmonary dysfunction * Difficult airway * History of anesthetic drug allergy * Chronic sedative or analgesic use * Preoperative volume depletion * Overt painful stimuli

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hemodynamic instability during anesthesia Induction anesthesia Intubation

Contacts and locations

Locations

  • Aoyang Hospital Affiliated to Jiangsu University

    Zhangjiagang, Jiangsu, 215600, China

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