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Can a new AI denoiser make Low-Dose CT scans crystal clear?

NCT ID NCT07759011

Knowledge-focused Sponsor: Philips Clinical & Medical Affairs Global Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 11, 2026 · Last updated Aug 12, 2026 · Updated 1 time

Summary

This study tests whether a new image-processing method called Spectral Precise Image (SPI) intelligent denoising can produce high-quality CT images from low-dose scans, compared to the standard iDose4 method. About 80 healthy volunteers will undergo CT scans at both low and routine radiation doses. Radiologists will rate the images for quality and noise to see if SPI allows for lower radiation exposure without sacrificing clarity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
CT radiation scan with two image reconstruction methods: SPI intelligent denoising and iDose4
What this could lead to
If SPI produces better images at lower radiation doses, it could enable safer CT scans with reduced radiation exposure for patients.
What could go wrong
This is a small, early-stage imaging study in healthy volunteers, so results may not apply to patients with different body types or conditions. Image quality is subjective and may not translate to better diagnostic accuracy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jul 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 ≤ age ≤ 75 years. * 18 kg/m² ≤ BMI ≤ 28 kg/m². * Conscious, able to cooperate, and competent to perform study procedures. Voluntarily agrees to participate in this clinical study and has signed the informed consent form. * Women of childbearing potential must have a negative pregnancy test and have no plans to become pregnant during the next 6 months. Exclusion Criteria: * Persons without full civil capacity. * Pregnant or breastfeeding women. * Any other conditions that, in the investigator's judgment, make the subject unsuitable for participation in this clinical study.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Volunteers

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • No. 107 Wenhua West Road, Lixia District

    Jinan, Shandong, 250011, China

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