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Can slower dialysis fluid flow still clean blood effectively?

NCT ID NCT07360769

Knowledge-focused Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether using a lower dialysate flow rate (300 ml/min instead of the usual 500 ml/min) affects how well dialysis cleans the blood, how quickly patients recover after treatment, and their overall quality of life. Eighty adults with end-stage kidney disease on maintenance hemodialysis took part. Each patient had one week of standard flow and one week of low flow to compare results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lower dialysate flow rate (300 ml/min)
What this could lead to
If successful, this could show that using less dialysate fluid is safe and effective, potentially reducing costs and environmental waste in dialysis.
What could go wrong
This is a small, completed study with only 80 participants, so results may not apply to all kidney patients. Lower flow might reduce dialysis adequacy for some individuals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

80 people

The number who actually took part.

Started

Jun 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * ESKD patients more than or equal 18 years old, on maintenance HD thrice weekly for more than three months and each session lasts for 4 hours. * All patients will receive HD via an arterio-venous fistula. * All patients will receive HD via the same type of HD machine and the blood pump will be set at 300ml/min. * All patients will receive the same type of HD membranes and every effort will be made to achieve the dry weight of the patients. Exclusion Criteria : * Critically ill and hospitalized ESKD patients. * Mentally disabled patients. * Patients with terminal malignancy or receiving chemotherapy. * Patients receiving immune suppression treatment.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

End stage kidney disease (ESRD)

Contacts and locations

Locations

  • Faculty of Medicine Alexandria University

    Alexandria, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.