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Blood cell ratio may flag delirium risk in elderly surgery patients

NCT ID NCT07322744

Knowledge-focused Sponsor: Chinese PLA General Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed study looked at whether a simple blood test measuring the ratio of two types of white blood cells (lymphocytes to monocytes) could help predict postoperative delirium—a state of confusion after surgery—in older adults. Researchers studied over 6,400 surgical patients aged 65 and older, also considering their frailty status. The goal was to see if this blood marker could better identify those at risk, potentially leading to earlier preventive measures.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could help doctors identify older patients at higher risk of confusion after surgery, allowing for better preventive care.
What could go wrong
This is an observational study, not a treatment trial. It cannot prove cause and effect, and results may not apply to all surgical patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

6,475 people

The number who actually took part.

Started

Apr 2020

Finished

Dec 2023

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients were grouped according to the preoperative lymphocyte-to-monocyte ratio (LMR) and were further stratified into subgroups based on frailty status, which was assessed one day before surgery using the FRAIL scale. Postoperative delirium was assessed using the 3-Minute Diagnostic Interview for Confusion Assessment Method (3D-CAM) for seven consecutive postoperative days or until hospital discharge, whichever occurred first.

Ages

65 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged ≥65 years; * Underwent elective noncardiac, nonneurosurgical procedures; * Completed the preoperative health and functional status questionnaire. Exclusion Criteria: * Severe dementia, language disorders, significant hearing or visual impairments, or coma; * Cognitive function below the Mini-Mental State Examination thresholds (\<18 for illiterate individuals, \<21 for individuals with primary education, and \<25 for individuals with secondary education or higher); * Surgery performed under local anesthesia or monitored anesthesia care; * Missing lymphocyte or monocyte count data; * Missing postoperative delirium assessment; * Incomplete preoperative FRAIL scale evaluation; * Missing data for more than 20% of covariates.

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Conditions

The condition(s) this trial relates to.

Emergence Delirium Frailty

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Frailty at older adults Lymphocyte Postoperative delirium (POD)

Contacts and locations

Locations

  • 28 Fuxing Road, Haidian District

    Beijing, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.