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Can a new model forecast liver failure survival?

NCT ID NCT07548190

Knowledge-focused Sponsor: The Second Affiliated Hospital of Chongqing Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at 2000 patients with acute-on-chronic liver failure caused by hepatitis B. Researchers will collect blood samples and medical data to build a model that predicts survival and complications at different time points. The goal is to give doctors a better way to estimate prognosis, but no new treatment is being tested.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a tool that helps doctors predict how liver failure patients will do, guiding treatment decisions.
What could go wrong
This is an observational study, not a treatment trial. The model may not be accurate for all patients or in other hospitals.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 2,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2018

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Hospitalized patients diagnosed with Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) .

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: •Clinical diagnosis of Hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) Exclusion Criteria: * age \< 18 years * extrahepatic organ failure unrelated to ACLF * active malignancy * co-infection with other hepatitis viruses or human immunodeficiency virus (HIV) * prior liver transplantation * use of immunosuppressants within 6 months before enrollment * unclear history of antiviral therapy

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Conditions

The condition(s) this trial relates to.

liver failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Liver failure

Contacts and locations

Locations

  • Department of Infectious Diseases, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, The Second Affiliated Hospital, Chongqing Medical University

    Chongqing, China

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