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New citrate cocktail may dissolve tough kidney stones without surgery

NCT ID NCT07162974

Disease control Sponsor: Moscow State University of Medicine and Dentistry Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested a citrate mixture (citric acid, potassium bicarbonate, and sodium citrate) to dissolve coral-like urate kidney stones in 49 patients. The goal was to see if the treatment could shrink or eliminate stones, potentially avoiding surgery. Patients took a personalized dose to keep urine pH at 7.2, and doctors used CT scans to track stone size and density.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
citrate mixture (anhydrous citric acid, potassium bicarbonate, sodium citrate)
What this could lead to
If successful, this approach could offer a non-surgical way to dissolve certain kidney stones, reducing the need for invasive procedures.
What could go wrong
This was a small, single-group study with 49 participants and no comparison group. Results may not apply to all stone types or patients. The treatment requires careful pH monitoring and may not work for everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

49 people

The number who actually took part.

Started

Jan 2023

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Coral-shaped calculus, which fills one or more calyx and pelvis (K2-K4 according to the classification of coral-shaped concretions); * The urate composition of the kidney stone was confirmed using dual-energy MSCT; * Unimpaired or restored (by draining the kidney) urine outflow from the kidney; * Persistently acidic urine pH (pH 5.8 or less); * Stone density is 550 Hounsfield units or less; * Informed voluntary consent of the patient to participate in the study; * Patient's readiness for conservative treatment; * No contraindications to therapy with citrate mixtures;

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Conditions

The condition(s) this trial relates to.

acute urate nephropathy urolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Urolithiasis

Contacts and locations

Locations

  • Moscow state university of medicine and dentistry named after A.I. Evdokimov

    Moscow, 127473, Russia

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