Blood pressure pill may tame thick blood disorder

NCT ID NCT07594535

Disease control Sponsor: Mayo Clinic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 21, 2026 · Updated 1 time

Summary

This study tests if lisinopril, a common blood pressure drug, can lower red blood cell levels in people with polycythemia (too many red blood cells). Researchers will measure changes in hemoglobin, hematocrit, and a hormone called erythropoietin. The trial enrolls 30 adults with high red blood cell counts not caused by common genetic mutations or smoking.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 30 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Hemoglobin in Men: \>16.5 g/dL (10.3 mmol/L). * Hemoglobin in Women \>16.0 g/dL (10.0 mmol/L). * BMI 18-40 kg/m2. Exclusion Criteria: * Positive JAK2 gene linked to Polycythemia Vera. * Current smoker or previous heavy smoker (\>15 pack years) who quit less than 12 months prior to enrollment. * Resting SpO₂ ≤ 94% on room air. * Current or recent (within the past 6 months) use of testosterone or androgen supplementation. * Any confounding respiratory or renal disease, including diagnosed or suspected sleep apnea, or stage 3 and up of chronic kidney disease. * Any confounding hematologic disease that may alter hemoglobin level. * Currently treated with ACE inhibitors. * Currently treated with potassium-sparing diuretics. * Currently on SGLT2 or use within 4 weeks prior to screening. * Baseline systolic blood pressure ≤90 mmHg. * Baseline systolic blood pressure \>160 mmHg or diastolic blood pressure \>100 mmHg. * Occupational exposure associated with chronically elevated COHb (auto repair, etc.). * History of anaphylaxis or angioedema. * Pregnant or breastfeeding.

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Conditions

The condition(s) this trial relates to.

polycythemia secondary polycythemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polycythemia

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

2 sites. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Blood pressure pill may tame thick blood disorder

What the study statuses mean