Light at the end of the tunnel: bright light therapy may boost opioid recovery
NCT ID NCT06832007
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether morning bright light therapy can improve sleep and brain function in 105 adults recovering from opioid use disorder. Participants on stable medication will receive either bright or dim light for 30 minutes daily over two weeks. Researchers will measure sleep patterns, brain activity, and drug cravings to see if light therapy helps recovery.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 105 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2025
- Expected to finish
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Sep 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 60 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * All Participants * Between 18 and 60 years old * Fluent in English * Able to provide written informed consent OUD * DSM-5 diagnosis of an OUD. * ≥12 months of lifetime opioid use * Positive on urine drug screen for buprenorphine or methadone * Receiving opioid agonist therapy for OUD (e.g., methadone or buprenorphine) with a stable dose for the past month. Must have been stabilized on OMT medication, since the increasing of doses during induction phase might interfere with outcomes and unstable patients might experience strong withdrawal symptoms in the morning which makes them unsuitable for a home-based BLT. * Other substance use was not exclusionary, but opioids were identified as primary. Exclusion Criteria: All Participants * Head trauma with loss of consciousness for more than 30 minutes as determined by medical history. * history of seizures/epilepsy. * Pregnant and/or currently breast-feeding. * Presence of ferromagnetic objects in the body that are contraindicated for MRI or fear of enclosed spaces. * Eye disease including disease of the anterior and posterior segment of the eye, cataracts, retinopathy, glaucoma, amblyopia, scotoma, color or night blindness, corneal pathologies, macular degeneration, or retinitis pigmentosa reported by history or identified by eye exam * History of eye surgery * Chronic migraine triggered by bright light * worked night shift or traveled across\>2 time zones in the past month OUD * diagnosis of substance use disorder other than for opioids that was deemed to be primary * lifetime diagnosis of schizophrenia, bipolar disorder, or suicidality. * History of light treatment * Unstable dose of psychiatric medication (hypnotics, sleep aids, and antidepressants must be stable for 30 days before and during the study) HC * Current or past DSM-IV or DSM-5 diagnosis of a psychiatric disorder including substance use disorder (except for nicotine/caffeine). * Current DSM-5 sleep-wake disorders including insomnia disorder
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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University of Alabama at Birmingham
RECRUITINGBirmingham, Alabama, 35294, United States
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Other studies related to the condition(s) this trial covers.
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- Can a bed that changes temperature deepen your sleep?