Lemon balm scent may ease Kids' dental fear, study hopes
NCT ID NCT07592130
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether breathing in lemon balm essential oil can reduce anxiety and pain in children aged 6 to 10 during dental injections. Forty-five children will be randomly assigned to receive aromatherapy with one of two brands of lemon balm oil or standard care. Researchers will measure anxiety with a child-friendly questionnaire and observe pain behaviors during the procedure.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Melissa officinalis (lemon balm) essential oil
- What this could lead to
- If it works, this could offer a simple, non-drug way to help children feel calmer during dental visits.
- What could go wrong
- This is a small, early-phase trial with only 45 children, so results may not apply broadly. The effect may be due to the pleasant scent rather than the oil itself.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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About 45 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jun 2026
An estimate. Start dates often move.
- Expected to finish
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Feb 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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6 to 10 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Children aged 6 to 10 years at the time of enrollment. * Male or female pediatric patients in good general physical and mental health. * Require mandibular local anesthesia (inferior alveolar nerve block) for pulpotomy or pulpectomy of at least one primary molar. * No previous experience with dental local anesthesia. * Behavior classified as "positive" or "negative but accepting" (categories 2 or 3) according to the Frankl Behavior Rating Scale during the initial examination. * Ability of the child to understand simple verbal instructions appropriate for age. * Parent or legal guardian able and willing to sign written informed consent. * Child willing to provide verbal assent to participate in the study. Exclusion Criteria: * History of previous dental local anesthesia. * Presence of dental emergencies (e.g., acute infection, severe pain, or swelling) requiring urgent treatment. * Known diagnosis of neurological, psychiatric, developmental, or behavioral disorders that may interfere with cooperation or with the assessment of anxiety and pain. * Systemic diseases or medical conditions (American Society of Anesthesiologists \[ASA\] physical status III or higher) that increase procedural risk or preclude participation according to the investigator's judgment. * Current acute upper respiratory conditions, such as common cold, rhinitis, sinusitis, or nasal allergy that could alter the sense of smell or breathing comfort. * Known allergy, hypersensitivity, or adverse reaction to Melissa officinalis, other Lamiaceae plants, essential oils, or components of the products used in the study. * Use of anxiolytics, antidepressants, sedatives, or other psychotropic medications within the last 30 days. * Behavior rated as definitely negative (Frankl category 1) or definitely positive (Frankl category 4) at baseline. * Inability of parents or guardians to understand the study information or provide informed consent. * Participation in another clinical trial within the previous 30 days.
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As listed by the trial registrant
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How to take part
Only the study team decides who joins. These are the ways to reach them.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
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